©2019 by Dr. Jessica Amber Jennings.

Herff College of Engineering
The University of Memphis

GRANTS & CONTRACTS

ACTIVE SUPPORT

2018-2019
FedEx Institute of Technology

CYCLOPROPYL FATTY ACID SIGNALING MOLECULE ANALOGS AND METHODS FOR USE IN CONTROLLING MICROBIAL BIOFILMS

  • Synthesize library of analog compounds with varying chain length, head groups, and functional tail groups. 

  • Evaluate loading strategies and release of cyclopropyl-loaded biomaterials, This project provided the initial tools and resources to develop the synthetic strategies proposed and focuses on the initial screening of efficacy.  The proposed project expands upon this work to investigate these new molecules in a systematic approach and includes non-overlapping aims.

$20,000
Role: PI

2018-2019
State of Tennessee (University of Tennessee Health Science Center)

NOVEL 3D BIOFABRICATION METHODOLOGIES AND MANUFACTURING FOR ENHANCED TISSUE REGENERATION AND IMPLANTABLE DEVICES

 

  • Integrate state-of-the-art metallic, polymeric, and hybrid (combination of metal and polymer) additive manufacturing (AM) technologies and multi-disciplinary expertise that can contribute to establishing novel 3D bio fabrication methodologies achieving the above objectives to create successful regenerative platforms and devices.

$200,000
Role: CO-I

2017-2022
NIH 1R01 DE026759-01

Bumgardner (PI)

CHITOSAN GUIDED BONE REGENERATION MEMBRANES FOR DUAL LOCAL DELIVERY OF SIMVASTATIN AND RASPBERRY KETONE

 

  • This research project incorporates anti-inflammatory molecules with a growth promoting component into chitosan-based electrospun membranes for use as a guided bone regeneration membrane

$2,012,914
Role: CO-I

2015-2020
NIH 1R01 AR066050-01A1

Jennings (PI)

Investigating a Flexible, Degradable, Local Antimicrobial Delivery System
The goal of this project is to investigate an injectable delivery system for prevention and treatment of implant-associated infections.

$1,525,882
Role:  PI

Previous
2014-2015
Biomet, LLC                                                                                         Jennings (PI)

Orthopaedic evaluation of Biomet anti-infective coating
This study continues evaluation of antibiotic-loaded point-of-care coatings in a functional model of orthopaedic implant-associated infection.
$114,067
Role: PI

2014
Austin Medical Ventures                                                                       Jennings (PI)

In Vitro Evaluation of Chitosan Hydrogel Antimicrobial Diffusion
This study compared in vitro efficacy of experimental and commercially available veterinary topical wound products in inhibiting bacterial growth.
$2,000
Role:  PI

2014-2015
University of Memphis Faculty Research Grant                                      Jennings (PI)

Improved Biomimetic Co-culture Chamber Design for Tendon to Bone Interface Engineering
The goal of this project is to improve the design of a bioreactor with dual chambers designed to stimulate application-specific matrix deposition using tension and compression.
$6,000
Role:  PI

2014-2016
Microport Orthopedics                                                                          Jennings/Haggard (co-PIs)

Comparison of tissue damage using SuperPATH and traditional posterior techniques during Total Hip Arthroplasty. 
The goal of this study is to evaluate the effectiveness of the SuperPATH technique in reducing tissue damage during total hip arthroplasty compared to traditional and alternative surgical techniques.
$18,797
Role:  co-PI

2013-2018
FedEx Institute of Technology, Smart Biomaterials Center         Jennings/Bumgardner (co-PIs)

Dual Action Biomaterial Coatings to Prevent Implant Infection
This research project will develop a dual-purpose dental implant coating that promotes bone growth while preventing infection.
$100,000
Role:  co-PI

2013-2014
Biomet                                                                                                 Jennings (PI)

Infection prevention through implant coating
The goal of this research is to assess biofilm and infection prevention properties of a novel point-of-care implant coating.
$61,755
Role:  PI

2013
Amniogenix/BioD, LLC                                                                        Jennings/Bumgardner (PI)

Evaluation of cell viability in the processed amniotic membrane for regenerative applications
The goal of this study was to determine effects of processing steps on cell viability of amniotic membrane used to enhance healing.
$3,000
Role: PI

2012-2017
FedEx Institute of Technology (Smart Biomaterials Center)         Haggard (PI)

Smart stimuli-responsive biomaterials for local drug delivery
This study aims to design and engineer stimuli-responsive biomaterials for local drug delivery applications
$525,000
Role: Co-investigator

2011-2015
Defense Medical Research and Development Program                             Haggard (PI)

Antibiotic-loaded biopolymer sponge for prevention of polymicrobial wound infection
The goal of this study is to develop and evaluate the efficacy of antibiotic-loaded chitosan sponge local delivery devices in the prevention and treatment of polymicrobial wound infection.
$2,383,664
Role: Co-investigator

2011-2012
Memphis Research Consortium                                                                          Haggard (PI)

Enhanced Preclinical Evaluation and Assessment of Bone Graft Biomaterials
The goal of this study is to evaluate and refine animal models for the assessment of bone graft biomaterials.
$100,000
Role:  Co-investigator

2010-2012
Department of Defense Peer Reviewed Orthopaedic Research Program     Jennings (PI)

Controlled Delivery of Cis-2-decenoic Acid for the Prevention of Infection by Bacterial Biofilms
The goal of this study is to deliver a fatty acid compound to prevent bacterial biofilm formation in complex extremity injuries.
$134,544
Role:  PI

2009-2010
Sonoma Orthopedics                                                                             Jennings (PI)

Biocompatibility assessment of particles generated by drilling PEEK Optima implants
The goal of this study is to characterize the effects of intramedullary particulates on bone healing. 
$79,073
Role:  PI

2008-2011                  
US Army Institute of Surgical Research                                                              Haggard (PI)

Chitosan Hydrogels for Prevention of Wound Infection
The goal of this study is the development of an antibiotic, hemostatic wound dressing for use in traumatic battlefield injuries.
$968,791
Role:  Collaborator

2007-2008
US Army Institute of Surgical Research                                                              Haggard (PI)

Adjunctive Care for the Prevention of Acinetobacter-Induced Osteomyelitis Using a Fast-Acting Local Delivery System
The goal of this study was to develop a rapidly dissolving local delivery implant treatment of contaminated wounds.
$205,234
Role:  Collaborator

2007-2008
Orthopaedic Research and Education Foundation (OREF)                                   Haggard (PI)

Advanced Delivery of Antibiotics from Calcium Sulfate and Modified Calcium Sulfate Technology
The goal of this study is to determine the effects of a chitosan coating on antibiotic elution and bone formation.
$20,000
Role:  Collaborator