ACTIVE SUPPORT
GRANTS & CONTRACTS
2020-2025
NSF
TETHERED BIOFILM DISPERSAL SIGNALS FOR LONG-TERM PROTECTION OF ENGINEERING MATERIALS
The goal of this project is to functionalize biopolymers, metals, synthetic polymers, and ceramics with a biofilm-active fatty acid to achieve long term inhibition and dispersal of bacterial biofilms.
$543,552
Role: PI
2020-2023
Military Burn Research Program
ACYLATED ELECTROSPUN BIOPOLYMER MEMBRANES FOR BURN WOUND COVERAGE, INFECTION PREVENTION, AND PAIN RELIEF
The goal of this to develop antimicrobial and anesthetic wound dressings that prevent infection, relieve pain, and prevent burn wound conversion.
$499,315
Role: PI
2020-2023
UofM-Czech Academy of Sciences Mobility Projects
Bumgardner (PI)
NOVEL CHITOSAN-BASED ANGIOGENIC NANFIBROUS SCAFFOLDS FOR SKIN TISSUE ENGINEERING
The goal of this project is to evaluate angiogenic potential of electrospun chitosan for skin tissue engineering.
$37,500
Role: CO-I
2020-2022
Peer-Reviewed Medical Research Program Discovery Award
DEVELOPMENT OF ACYLATED NANOFIBROUS CHITOSAN MEMBRANES FOR PRE-HOSPITAL TRAUMATIC WOUND COVERAGE, INHIBITION, AND PAIN MITIGATION
$268,156
Role: CO-I
2020-2021
Monogram Orthopedics
CYTOCOMPATIBILITY AND ANTI-BIOFILM PROPERTIES OF ADDITIVE MANUFACTURED SILVER/CHITOSAN COATINGS
The goal of this project is to investigate antimicrobial coatings on titanium implants
$8,600
Role: PI
2019-2020
Austin Medical Ventures
CALCIUM SULFATE BONE GRAFT MATERIALS
Compare commercially available calcium sulfate systems for bone graft substitutes in pH, elution of antibiotics, activity against bacteria, and calcium release
$34,508
Role: CO-I
2018-2020
Abbott Diagnostics
ANTIMICROBIAL SUSCEPTIBILITY EVALUATION
Evaluate novel antimicrobial surfaces in Kirby Bauer antimicrobial assays
$12,555
Role: PI
2017-2022
NIH 1R01 DE026759-01
Bumgardner (PI)
CHITOSAN GUIDED BONE REGENERATION MEMBRANES FOR DUAL LOCAL DELIVERY OF SIMVASTATIN AND RASPBERRY KETONE
This research project incorporates anti-inflammatory molecules with a growth promoting component into chitosan-based electrospun membranes for use as a guided bone regeneration membrane.
$2,012,914
Role: CO-I
2015-2021
NIH 1R01 AR066050-01A1
Jennings (PI)
Investigating a Flexible, Degradable, Local Antimicrobial Delivery System
The goal of this project is to investigate an injectable delivery system for prevention and treatment of implant-associated infections
$1,525,882
Role: PI
PREVIOUS SUPPORT
2018-2019
FedEx Institute of Technology
Jennings (PI)
Cyclopropyl fatty acid signaling molecule analogs and methods for use in controlling microbial biofilms
This project provided the initial tools and resources to develop the synthetic strategies proposed and focuses on initial screening of efficacy. The proposed project expands upon this work to investigate these new molecules in a systematic approach.
$20,000
Role: PI
2018-2019
State of Tennessee (University of Tennessee Health Science Center)
Novel 3D biofabrication methodologies and manufacturing for enhanced tissue regeneration and implantable devices
Integrate state-of-the-art metallic, polymeric, and hybrid (combination of metal and polymer) additive manufacturing (AM) technologies and multi-disciplinary expertise that can contribute to establishing novel 3D biofabrication methodologies achieving the above objectives to create successful regenerative platforms and devices.
$200,000
Role: CO-I
2014-2015
Biomet, LLC
Jennings (PI)
Orthopaedic evaluation of Biomet anti-infective coating
This study continues the evaluation of antibiotic-loaded point-of-care coatings in a functional model of orthopaedic implant-associated infection.
$114,067
Role: PI
2014
Austin Medical Ventures
Jennings (PI)
In Vitro evaluation of chitosan hydrogel antimicrobial diffusion
This study compared in vitro efficacy of experimental and commercially available veterinary topical wound products in inhibiting bacterial growth.
$2,000
Role: PI
2014-2015
University of Memphis Faculty Research Grant
Jennings (PI)
Improved biomimetic co-culture chamber design for tendon to bone interface engineering
The goal of this project is to improve the design of a bioreactor with dual chambers designed to stimulate application-specific matrix deposition using tension and compression.
$6,000
Role: PI
2014-2016
Microport Orthopedics
Jennings/Haggard (co-PIs)
Comparison of tissue damage using SuperPATH and traditional posterior techniques during Total Hip Arthroplasty
The goal of this study is to evaluate the effectiveness of the SuperPATH technique in reducing tissue damage during total hip arthroplasty compared to traditional and alternative surgical techniques.
$18,797
Role: co-PI
2013-2018
FedEx Institute of Technology, Smart Biomaterials Center Jennings/Bumgardner (co-PIs)
Dual action biomaterial coatings to prevent implant infection
This research project will develop a dual-purpose dental implant coating that promotes bone growth while preventing infection.
$100,000
Role: co-PI
2013-2014
Biomet
Jennings (PI)
Infection prevention through implant coating
The goal of this research is to assess biofilm and infection prevention properties of a novel point-of-care implant coating.
$61,755
Role: PI
2013
Amniogenix/BioD, LLC
Jennings/Bumgardner (PI)
Evaluation of cell viability in the processed amniotic membrane for regenerative applications
The goal of this study was to determine effects of processing steps on cell viability of amniotic membrane used to enhance healing.
$3,000
Role: PI
2012-2017
FedEx Institute of Technology (Smart Biomaterials Center)
Haggard (PI)
Smart stimuli-responsive biomaterials for local drug delivery
This study aims to design and engineer stimuli-responsive biomaterials for local drug delivery applications.
$525,000
Role: Co-investigator
2011-2015
Defense Medical Research and Development Program
Haggard (PI)
Antibiotic-loaded biopolymer sponge for prevention of polymicrobial wound infection
The goal of this study is to develop and evaluate the efficacy of antibiotic-loaded chitosan sponge local delivery devices in the prevention and treatment of polymicrobial wound infection.
$2,383,664
Role: Co-investigator
2011-2012
Memphis Research Consortium
Haggard (PI)
Enhanced Preclinical Evaluation and Assessment of Bone Graft Biomaterials
The goal of this study is to evaluate and refine animal models for the assessment of bone graft biomaterials.
$100,000
Role: Co-investigator
2010-2012
Department of Defense Peer Reviewed Orthopaedic Research Program
Jennings (PI)
Controlled Delivery of Cis-2-decenoic Acid for the Prevention of Infection by Bacterial Biofilms
The goal of this study is to deliver a fatty acid compound to prevent bacterial biofilm formation in complex extremity injuries.
$134,544
Role: PI
2009-2010
Sonoma Orthopedics
Jennings (PI)
Biocompatibility assessment of particles generated by drilling PEEK Optima implants
The goal of this study is to characterize the effects of intramedullary particulates on bone healing.
$79,073
Role: PI
2008-2011
US Army Institute of Surgical Research
Haggard (PI)
Chitosan hydrogels for prevention of wound infection
The goal of this study is the development of an antibiotic, hemostatic wound dressing for use in traumatic battlefield injuries.
$968,791
Role: Collaborator
2007-2008
US Army Institute of Surgical Research
Haggard (PI)
Adjunctive care for the prevention of acinetobacter-induced osteomyelitis using a fast-acting local delivery system
The goal of this study was to develop a rapidly dissolving local delivery implant treatment of contaminated wounds.
$205,234
Role: Collaborator
2007-2008
Orthopaedic Research and Education Foundation (OREF)
Haggard (PI)
Advanced delivery of antibiotics from calcium sulfate and modified calcium sulfate technology
The goal of this study is to determine the effects of a chitosan coating on antibiotic elution and bone formation.
$20,000
Role: Collaborator