GRANTS & CONTRACTS
FedEx Institute of Technology
CYCLOPROPYL FATTY ACID SIGNALING MOLECULE ANALOGS AND METHODS FOR USE IN CONTROLLING MICROBIAL BIOFILMS
Synthesize library of analog compounds with varying chain length, head groups, and functional tail groups.
Evaluate loading strategies and release of cyclopropyl-loaded biomaterials, This project provided the initial tools and resources to develop the synthetic strategies proposed and focuses on the initial screening of efficacy. The proposed project expands upon this work to investigate these new molecules in a systematic approach and includes non-overlapping aims.
State of Tennessee (University of Tennessee Health Science Center)
NOVEL 3D BIOFABRICATION METHODOLOGIES AND MANUFACTURING FOR ENHANCED TISSUE REGENERATION AND IMPLANTABLE DEVICES
Integrate state-of-the-art metallic, polymeric, and hybrid (combination of metal and polymer) additive manufacturing (AM) technologies and multi-disciplinary expertise that can contribute to establishing novel 3D bio fabrication methodologies achieving the above objectives to create successful regenerative platforms and devices.
NIH 1R01 DE026759-01
CHITOSAN GUIDED BONE REGENERATION MEMBRANES FOR DUAL LOCAL DELIVERY OF SIMVASTATIN AND RASPBERRY KETONE
This research project incorporates anti-inflammatory molecules with a growth promoting component into chitosan-based electrospun membranes for use as a guided bone regeneration membrane
NIH 1R01 AR066050-01A1
Investigating a Flexible, Degradable, Local Antimicrobial Delivery System
The goal of this project is to investigate an injectable delivery system for prevention and treatment of implant-associated infections.
Biomet, LLC Jennings (PI)
Orthopaedic evaluation of Biomet anti-infective coating
This study continues evaluation of antibiotic-loaded point-of-care coatings in a functional model of orthopaedic implant-associated infection.
Austin Medical Ventures Jennings (PI)
In Vitro Evaluation of Chitosan Hydrogel Antimicrobial Diffusion
This study compared in vitro efficacy of experimental and commercially available veterinary topical wound products in inhibiting bacterial growth.
University of Memphis Faculty Research Grant Jennings (PI)
Improved Biomimetic Co-culture Chamber Design for Tendon to Bone Interface Engineering
The goal of this project is to improve the design of a bioreactor with dual chambers designed to stimulate application-specific matrix deposition using tension and compression.
Microport Orthopedics Jennings/Haggard (co-PIs)
Comparison of tissue damage using SuperPATH and traditional posterior techniques during Total Hip Arthroplasty.
The goal of this study is to evaluate the effectiveness of the SuperPATH technique in reducing tissue damage during total hip arthroplasty compared to traditional and alternative surgical techniques.
FedEx Institute of Technology, Smart Biomaterials Center Jennings/Bumgardner (co-PIs)
Dual Action Biomaterial Coatings to Prevent Implant Infection
This research project will develop a dual-purpose dental implant coating that promotes bone growth while preventing infection.
Biomet Jennings (PI)
Infection prevention through implant coating
The goal of this research is to assess biofilm and infection prevention properties of a novel point-of-care implant coating.
Amniogenix/BioD, LLC Jennings/Bumgardner (PI)
Evaluation of cell viability in the processed amniotic membrane for regenerative applications
The goal of this study was to determine effects of processing steps on cell viability of amniotic membrane used to enhance healing.
FedEx Institute of Technology (Smart Biomaterials Center) Haggard (PI)
Smart stimuli-responsive biomaterials for local drug delivery
This study aims to design and engineer stimuli-responsive biomaterials for local drug delivery applications
Defense Medical Research and Development Program Haggard (PI)
Antibiotic-loaded biopolymer sponge for prevention of polymicrobial wound infection
The goal of this study is to develop and evaluate the efficacy of antibiotic-loaded chitosan sponge local delivery devices in the prevention and treatment of polymicrobial wound infection.
Memphis Research Consortium Haggard (PI)
Enhanced Preclinical Evaluation and Assessment of Bone Graft Biomaterials
The goal of this study is to evaluate and refine animal models for the assessment of bone graft biomaterials.
Department of Defense Peer Reviewed Orthopaedic Research Program Jennings (PI)
Controlled Delivery of Cis-2-decenoic Acid for the Prevention of Infection by Bacterial Biofilms
The goal of this study is to deliver a fatty acid compound to prevent bacterial biofilm formation in complex extremity injuries.
Sonoma Orthopedics Jennings (PI)
Biocompatibility assessment of particles generated by drilling PEEK Optima implants
The goal of this study is to characterize the effects of intramedullary particulates on bone healing.
US Army Institute of Surgical Research Haggard (PI)
Chitosan Hydrogels for Prevention of Wound Infection
The goal of this study is the development of an antibiotic, hemostatic wound dressing for use in traumatic battlefield injuries.
US Army Institute of Surgical Research Haggard (PI)
Adjunctive Care for the Prevention of Acinetobacter-Induced Osteomyelitis Using a Fast-Acting Local Delivery System
The goal of this study was to develop a rapidly dissolving local delivery implant treatment of contaminated wounds.
Orthopaedic Research and Education Foundation (OREF) Haggard (PI)
Advanced Delivery of Antibiotics from Calcium Sulfate and Modified Calcium Sulfate Technology
The goal of this study is to determine the effects of a chitosan coating on antibiotic elution and bone formation.